For list of publications: PubMed Google Scholar Scopus ORCID
Chronological Order
2024
Benesch MGK, Nurkin SJ. (2024) Robotic Rectal Excision, in Atlas of Retroperitoneal Surgery, Alexander Shifrin, Alexander Itskovich, Sylvie Bonvalot, Barry Feig (Ed.), Springer. (Accepted).
Benesch MGK, Wu R, Rog CJ, Brindley DN, Ishikawa T, Takabe K. (2024) Insights into Lysophosphatidate-Mediated Signaling in the Pancreatic Ductal Adenocarcinoma Tumor Microenvironment: A Survey of Pathway Gene Expression. Am. J. Cancer Res. 14, 4004-4027. PUBMED
Benesch MGK, Cherkassky L, Nurkin SJ. (2024). Multi-omic analysis: a possible platform towards personalized and adaptable cancer treatment. Ann. Surg. Oncol. 31, 4831-4833. 10.1245/s10434-024-15449-9 PUBMED
Benesch MGK, Ramos-Santillan VO, Rog CJ, Nelson ED, Takabe K. (2024). Epidemiology of Adenosquamous Carcinomas. World J. Oncol. 15, 432-453. doi: 10.14740/wjon1845. PUBMED
Wu R, Horimoto Y, Oshi M, Benesch MGK, Khoury T, Ishikawa T, Takabe K. (2024) Emerging Measurements for Tumor-Infiltrating Lymphocytes (TILs) in Breast Cancer. Jpn. J. Clin. Oncol. (In Press) 10.1093/jjco/hyae033. PUBMED
Nelson ED, Benesch MGK, Wu R, Ishikawa T, Takabe K. (2024) High EIF4EBP1 Expression Reflects mTOR Pathway Activity and Cancer Cell Proliferation and is a Biomarker for Poor Breast Cancer Prognosis. Am. J. Cancer Res. 14, 227-242. PUBMED
Benesch MGK, Tang X, Brindley DN, Takabe K. (2024) Title Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer. World J. Oncol. 15, 1-13. doi: 10.14740/wjon1762. PUBMED
Benesch MGK, Faller J, Skitzki JJ. (2024) Cutaneous Cancer Surgery, in Anesthesia for Oncological Surgery, 1st edition, Jeffery Huang, Jiapeng Huang, Henry Liu (Ed.), ISBN: 978-3031509766, Springer. 403-407. doi: 10.1007/978-3-031-50977-3_61
Bruno FP, Degani-Costa LH, Prasad KKL, Gushken F, Szlejf C, Tokeshi AB, Tehrani YF, Kaufman D, Kumar PSS, Jamir L, Benesch MGK, Ryan MG, Lotay H, Fuld JP, Fidalgo TM. (2024) Medical trainees’ knowledge and attitudes towards electronic cigarettes and Hookah: A multinational survey study. Respir. Care 69, 306-316. doi: 10.4187/respcare.11042. PUBMED
Benesch MGK, Nelson ED, O’Brien SBL. (2024) Location Has Prognostic Impact on the Outcome of Colorectal Mucinous Adenocarcinomas. Cancers 16, E147. doi: 10.3390/cancers16010147. PUBMED
Benesch MGK, Skitzki JJ. (2024) Impact of Anesthesia Choice in Cutaneous Melanoma Surgery. Melanoma Res. 34, 16-21. doi: 10.1097/cmr.0000000000000936. PUBMED
2023
Benesch MGK, Nelson ED, O’Brien SBL. (2023) Malignant Transformation of Long-Standing Ileal Crohn’s Disease Likely Favors Signet Ring Cell Adenocarcinoma Histology. World J. Oncol. 14, 447-456. doi: 10.14740/wjon1605. PUBMED
Takabe K, Benesch MGK, Chida K (2023) World Journal of Oncology Has Gained an Impact Factor of 5.2 by Journal Citation Reports. World J. Oncol. 14, 231-233. doi: 10.14740/wjon1687. PUBMED
Benesch MGK, Wu R, Tang X, Brindley DN, Ishikawa T, Takabe K. (2023) Autotaxin Production in in the Human Breast Cancer Tumor Microenvironment Mitigates Tumor Progression in Early Breast Cancers. Am. J. Cancer Res. 13, 2790-2813. PUBMED
Wu R, Oshi M, Asaoka M, Li Yan L, Benesch MGK, Khoury T, Nagahashi M, Miyoshi Y, Endo I, Ishikawa T, Takabe T. (2023) Intratumoral Tumor Infiltrating Lymphocytes (TILs) are Associated With Cell Proliferation and Better Survival But Not Always With Chemotherapy Response in Breast Cancer. Ann. Surg. 278, 587-597. doi: 10.1097/sla.0000000000005954. PUBMED
Benesch MGK, Wu R, Tang X, Brindley DN, Ishikawa T, Takabe K. (2023) Lysophosphatidic Acid Receptor Signaling in the Human Breast Cancer Tumor Microenvironment Elicits Receptor-Dependent Effects on Tumor Progression. Int. J. Mol. Sci, 24, 9812. doi: 10.3390/ijms24129812. PUBMED
Benesch MGK, Wu R, Tang X, Brindley DN, Ishikawa T, Takabe K. (2023) Decreased Lipid Phosphate Phosphatase-1/3 and Increased Lipid Phosphate Phosphatase 2 Expression in the Human Breast Cancer Tumor Microenvironment Promotes Tumor Progression and Immune System Evasion. Cancers 15, 2299, doi: 10.3390/cancers15082299. PUBMED
Degani-Costa LH, Bruno FP, Gushken F, Szlejf C, Tokeski AB, Tehrani YF, Kaufman D, Prasad KKL, Kumar PSS, Jamir L, Benesch MGK, Ryan MG, Lotay H, Fuld JP, Fidalgo TM. (2023) Vaping and Hookah Use Among Medical Trainees: A Multinational Survey Study. Am. J. Prev. Med. 65, 940-949. doi: 10.1016/j.amepre.2023.05.009. PUBMED
Takabe K, Benesch MGK. (2023) Biomarker Research in World Journal of Oncology. World J. Oncol. 14, 1-3. doi: 10.14740/wjon1577. PUBMED
Benesch MGK, Mathieson A, O’Brien SBL. (2023) Effects of Tumor Localization, Age, and Stage on the Outcomes of Gastric and Colorectal Signet Ring Cell Adenocarcinomas. Cancers 15, 714. doi: 10.3390/cancers15030714. PUBMED
2022
Takabe K, Benesch MGK. (2022) Types of Cancer and Research Covered in World Journal of Oncology. World J. Oncol. 13, 325-328. doi: 10.14740/wjon1558. PUBMED
Benesch MGK, Wu R, Menon G, Takabe K. (2022) High beta integrin expression is differentially associated with worsened pancreatic ductal adenocarcinoma outcomes. Am. J. Cancer Res. 12, 5403-5424. PUBMED
Benesch MGK, O’Brien SBL. (2022) Epidemiology of Undifferentiated Carcinomas. Cancers 14, 5819. doi: 10.3390/cancers14235819. PUBMED
Shanahan JJ, LeBlanc DM, Courage ER, Benesch MGK, Hickey KE, Hartwig KA, Armstrong CD, Engelbrecht R, Fagan MG, Borgoankar MR, Pace DE. (2022) Characteristics of Interval Colorectal Cancer: A Canadian Retrospective Population-Level Analysis from Newfoundland and Labrador. Curr. Oncol. 29, 9150-9162. doi: 10.3390/curroncol29120716. PUBMED
Takabe K, Day V, Benesch MGK (2022) The dimensions of reports from around the world that address diversity in oncology. World J. Oncol. 13, 241-243. doi: 10.14740/wjon1535. PUBMED
Oshi M, Tokumaru T, Benesch MGK, Sugito N, Wu R, Yan L, Yamada AA, Chisima T, Ishikawa T, Endo I, Takabe K. (2022) High miR-99b expression is assocatied with cell proliferation and worse patient outcomes in breast cancer. Am. J. Cancer Res. 12, 4840-4852. PUBMED
Benesch MGK, Mathieson A, Pace DE. (2022) Research and Surgical Residency: Moving Beyond One-and-Done Projects and Motivating for Scholarly Excellence. Can. J. Surg. 65, E485-E486. doi: 10.1503/cjs.013821. PUBMED
Benesch MGK, O’Driscoll MF. (2022) Pneumatosis Intestinalis of the Colon and Greater Omentum following Small Bowel Resection. Case Rep. Surg. 2022, 2670244. doi: 10.1155/2022/2670244. PUBMED
Benesch MGK, Mathieson A. (2022) Gastric Signet Ring Cell Adenocarcinoma with Delayed Retroperitoneal Metastasis and Fibrosis. Case Rep. Oncol. 15, 114–119. doi: 10.1159/000521888. PUBMED
2021
Benesch MGK, Howard CL, Smith CG. (2021) Endoscopic management of a nail-magnet aggregation impacted in the terminal ileum: a case report. J. Surg. Case. Rep. 2021(6), rjab259. doi: 10.1093/jscr/rjab259. PUBMED
Benesch MGK, Bursey SR, O’Connell AC, Ryan MG, Howard CL, Stockley CC, Matheison A. (2021) CDH1 Gene Mutation Hereditary Diffuse Gastric Cancer Outcomes: Analysis of a Large Cohort, Systematic Review of Endoscopic Surveillance, and Secondary Cancer Risk Postulation. Cancers 13, 2622. doi: 10.3390/cancers13112622. PUBMED
2020
Benesch MGK, Mathieson A. (2020) Epidemiology of Mucinous Adenocarcinomas. Cancers 12, 3193. doi: 10.3390/cancers12113193. PUBMED
Benesch MGK, Bussey ASD. (2020) Necrotizing fasciitis from perforated sigmoid diverticulitis with subsequent pyoderma gangrenosum: a case report. J. Surg. Case. Rep. 2020(9), rjaa282. doi: 10.1093/jscr/rjaa282. PUBMED
Brindley DN, Tang X, Meng G, Benesch MGK. (2020) Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer. Int. J. Mol. Sci. 21, 5938. doi: 10.3390/ijms21165938. PUBMED
Benesch MGK, Mathieson A. (2020) Epidemiology of Signet Ring Cell Adenocarcinomas. Cancers 12, 1544. doi: 10.3390/cancers12061544. PUBMED
Tang X, Benesch MGK, Brindley DN. (2020) Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy. (Invited Review) Biochim. Biophys. Acta 1865, 158716. doi: 10.1016/1.bbalip.2020.158716. PUBMED
Benesch MGK, Tang X, Brindley DN. (2020) Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae. (Invited Review) Cancers 12, 374. doi: 10.3390/cancers12020374. PUBMED
Tang X, Wuest M, Benesch MGK, Dufour J, Heckmann B, Murray D, Wuest F, Brindley DN. (2020) Inhibition of autotaxin with GLPG1690 increases the efficacy of radiotherapy and chemotherapy in a mouse model of breast cancer. Mol. Cancer Ther. 19, 63-74. doi: 10.1158/1535-7163.MCT-19-0386. PUBMED
2019
Yang Z, Tang X, Meng G, Benesch MGK, Mackova M, Belon AP, Serrano-Lomelin J, Goping IS, Brindley DN, Hemmings DG. (2019) Latent cytomegalovirus infection in female mice increases breast cancer metastasis. Cancers 11, 447. doi: 10.3390/cancers11040447. PUBMED
2018
Benesch MGK, Iqbal SJ. (2018) Novel psychoactive substances: overdose of 3-fluorophenmetrazine (3-FPM) and etizolam in a 33-year-old man. BMJ Case Rep. 2018:bcr2018224995. doi: 10.1136/bcr-2018-224995. PUBMED
Benesch MGK, MacIntyre ITK, McMullen TPW, Brindley DN. (2018) Coming of Age for Autotaxin and Lysophosphatidate Signaling: Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation. (Invited Review) Cancers 10, 73. doi: 10.3390/cancers10030073. PUBMED
2017
Zhou TE, Barton K, Cook E, Benesch MGK, Jette N, Moderie C, Ondrusova K, Lees C, Steadman PE, Marvasti TI, Mirali S, Liu PJ, Babadagli E, Abraham KJ, Zaslavsky K. (2017) Scientific Overview on CSCI-CITAC Annual General Meeting and 2016 Young Investigators’ Forum. Clin. Inves. Med. 40, E211-E217. doi: 10.25011/cim.v40i5.28626. PUBMED
Benesch MGK, Yang Z, Tang X, Meng G, Brindley DN. (2017) Lysophosphatidate Signaling Inhibition: The Tumor Microenvironment’s New Nemesis. (Invited Review) Trends Cancer 3, 748-752. doi: 10.1016/j.trecan.2017.09.004. PUBMED
Meng G, Tang X, Yang Z, Benesch MGK, Marshall A, Murray D, Hemmings DG, Wuest F, McMullen TPW, Brindley DN. (2017) Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. FASEB J. 31, 4064-4077. doi: 10.1096/fj.201700159R. PUBMED
2016
Zhao E, Zhou, E, Benesch MGK, Dey A, Liu P, Steadman P, Zaslavsky K, Schneider R, Kuzyk A. (2016) Scientific Overview: CSCI-CITAC Annual General Meeting and Young Investigators’ Forum 2015. Clin. Inves. Med. 39, E142-E149. doi: 10.25011/cim.v39i5.27146. PUBMED
Lopez-Campistrous A, Ekpe Adewuyi E, Benesch MGK, Ko YM, Lai R, Theisen A, Dewald J, Wang P, Williams DC, Vos LJ, Brindley DN, McMullen TPW. (2016)
PDGFRα regulates follicular cell differentiation driving treatment resistance and disease recurrence in papillary thyroid cancer. EBioMedicine 12, 86-97. doi: 10.1016/j.ebiom.2016.09.007. PUBMEDJones AA, Ng E, Deguise M-O, Mak L, Ouyang B, Sivapragasam M., MacNairn IAS, Nath S, Benesch MGK, Forrest L, Wang X. (2016) MD/PhD training in Canada: Results from a national trainee and program director review. Clin. Inves. Med. 39, E132-E139. doi: 10.25011/cim.v39i4.27092. PUBMED
Volodko N, Salla M, Zara A, Abulghasem E-A, Vincent K, Benesch MGK, McMullen TPW, Bathe OF, Postovit L, Baksh S. (2016) RASSF1A site specific methylation hotspots in cancer and correlation with RASSF1C and MOAP-1. Cancers 8, 55. doi: 10.3390/cancers8060055. PUBMED
Bekele RT, Venkatraman G, Liu R-Z, Tang X, Mi S, Benesch MGK, Mackey JR, Godbout R, Curtis JR, McMullen TPW, Brindley DN. (2016) Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance. Sci. Rep. 6, 21164. doi: 10.1038/srep21164. PUBMED
Benesch MGK, McElhaney RN. (2016) A comparative differential scanning calorimetry of the effects of cholesterol and various oxysterols on the thermotropic behavior of dipalmitoylphosphatidylcholine bilayer membranes. Chem. Phys. Lipids 195, 21-33. doi: 10.1016/j.chemphyslip.2015.11.003. PUBMED
Benesch MGK, Lewis RNAH, Mannock DA, McElhaney RN. (2016) A calorimetric and spectroscopic comparison of the effects of cholesterol and its sulfur-containing analogs thiocholesterol and cholesterol sulfate on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Biochim. Biophys. Acta 1858, 168-180. doi: 10.1016/j.bbamem.2015.11.006. PUBMED
Benesch MGK, Tang X, Venkatraman G, Bekele RT, Brindley DN. (2016) Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo. (Invited Review) J. Biomed. Res. 30, 272-284. doi: 10.7555/JBR.30.20150058. PUBMED
2015
Benesch MGK, Lewis RNAH, McElhaney RN. (2015) A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Chem. Phys. Lipids 191, 123-135. doi: 10.1016/j.chemphyslip.2015.09.002. PUBMED
Benesch MGK, Tang X, Dewald J, Dong WF, Mackey JR, McMullen TPW, Brindley DN. (2015) Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast tumor progression. FASEB J. 29, 3990-4000. doi: 10.1096/fj.15-274480. PUBMED
Benesch MGK, Lewis RNAH, McElhaney RN. (2015) On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylglycerol and tetramyristoylcardiolipin. Biochim. Biophys. Acta 1848, 2878-2888. doi: 10.1016/j.bbamem.2015.08.003. PUBMED
Benesch MGK, Ko YM, Tang X, Dewald J, Lopez-Campistrous A, Zhao YY, Lai R, Curtis JM, Brindley DN, McMullen TPW. (2015) Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. Endocr. Relat. Cancer 22, 593-607. doi: 10.1530/ERC-15-0045. PUBMED
Tang X, Benesch MGK, Brindley DN. (2015) Lipid phosphate phosphatases and their roles in pathophysiology. (Invited Review) J. Lipid Res. 56, 2048-2060. doi: 10.1194/jlr.R058362. PUBMED
Benesch MGK, Zhao YY, Curtis JM, McMullen TPW, Brindley DN. (2015) Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. J. Lipid Res. 56, 1134-1144. doi: 10.1194/jlr.M057661. PUBMED
Mannock DA, Benesch MGK, Lewis RNAH, McElhaney RN. (2015) A comparative calormetric and spectroscopic study of the effects of cholesterol and of the plant sterols b-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Biochim. Biophys. Acta 1848, 1629-1638. doi: 10.1016/j.bbamem.2015.04.009. PUBMED
Benesch MGK, Lewis RNAH, Mannock DA, McElhaney RN. (2015) A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. Chem. Phys. Lipids 188, 10-26. doi: 10.1016/j.chemphyslip.2015.03.002. PUBMED
Benesch MGK, Lewis RNAH, Mannock DA, McElhaney RN. (2015) A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs. Chem. Phys. Lipids 187, 34-49. doi: 10.1016/j.chemphyslip.2015.02.002. PUBMED
Brindley DN, Benesch MGK, Murph MM. (2015) Autotaxin - An Enzymatic Augmenter of Malignant Progression Linked to Inflammation, in Melanoma - Current Clinical Management and Future Therapeutics, Prof. Mandi Murph (Ed.), ISBN: 978-953-51-2036-0, InTech. (Invited Review) doi: 10.5772/59013.
Venkatraman G, Benesch MGK, Tang X, Dewald J, McMullen TPW, Brindley DN. (2015) Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: Implications for cancer treatment. FASEB J. 29, 772-785. doi: 10.1096/fj.14-262659. PUBMED
2014
Tang X, Benesch MGK, Dewald J, Zhao YY, Pathwardhan N, Santos W, Curtis JM, McMullen TPW, Brindley DN. (2014) Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. J. Lipid Res. 55, 2389-2400. doi: 10.1194/jlr.M053462. PUBMED
Benesch MGK, Lewis RNAH, Mannock DA, McElhaney RN. (2014) A DSC and FTIR spectroscopic study of the effects of the epimeric 4,6-cholestadien-3-ols and 4,6-cholestadien-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. Chem. Phys. Lipids 183, 142-158. doi: 10.1016/j.chemphyslip.2014.06.003. PUBMED
Benesch MGK, McElhaney RN. (2014) A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayer membranes. Biochim. Biophys. Acta 1838, 1941-1949. doi: 10.1016/j.bbamem.2014.03.019. PUBMED
Kok BPC, Skene-Arnold TD, Ling J, Benesch MGK, Dewald J, Harris TE, Holmes CFB, Brindley DN. (2014) Conserved residues in the N-terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation and phosphatidate phosphatase activity. J. Biol Chem. 289, 10876-10886. doi: 10.1074/jbc.M114.552612. PUBMED
Benesch MGK, Ko YM, Tang X, McMullen TPW, Brindley DN. (2014) Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions. (Invited Review) FEBS Letters 588, 2712-2727. doi: 10.1016/j.febslet.2014.02.009. PUBMED
Benesch MGK, Tang X, Maeda T, Ohhata A, Zhao Y, Kok BPC, Dewald J, Hitt M, Curtis JM, McMullen TPW, Brindley DN. (2014) Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. FASEB J. 28, 2655-2666. doi: 10.1096/fj.13-248641. PUBMED
Benesch MGK, Mannock DA, Lewis RNAH, McElhaney RN. (2014) A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. Chem. Phys. Lipids 177, 71-90. doi: 10.1016/j.chemphyslip.2013.11.008. PUBMED
2011
Benesch MGK, Mannock DA, Lewis RNAH, McElhaney RN. (2011) A calorimetric and spectroscopic comparison of the effects of lathosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Biochemistry 50, 9982-9997. doi: 10.1021/bi200721j. PUBMED
Benesch MGK, Mannock DA, McElhaney RN. (2011) Sterol chemical configuration and conformation influence the thermotropic phase behaviour of dipalmitoylphosphatidylcholine mixtures containing 5b-cholestan-3b- and -3a-ol. Chem. Phys. Lipids 164, 70-77. doi: 10.1016/j.chemphyslip.2010.10.005. PUBMED
Benesch MGK, Mannock DA, McElhaney RN. (2011) Sterol chemical configuration influences the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayers containing 5a-cholestan-3b- and 3a-ol. Chem. Phys. Lipids 164, 62-69. doi: 10.1016/j.chemphyslip.2010.10.003. PUBMED
Frias M, Benesch MGK, Lewis RNAH, McElhaney RN. (2011) On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylethanolamine and tetramyristoylcardiolipin. Biochim. Biophys. Acta 1808, 774-783. doi: 10.1016/j.bbamem.2010.12.010. PUBMED